The science of Sanguinity.The proof of principle is strong for our approach. Application of our algorithms can span age and condition. We have shown expression of selected genes in blood samples predicts which children with autism will respond to drugs that improve behavioral outcome. A different set of genes expressed in blood predicts stroke patients who will have brain hemorrhage after receiving clot-dissolving drug treatment. In all cases, the gene transcripts expressed show the responder pattern before and treatment is provided. That means appropriate planning and testing could be used to pinpoint individuals most likely to be right for your trial.
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Autism and risperidoneGene Expression in Blood Is Associated With Risperidone Response in Children With Autism Spectrum Disorders L Lit, F R Sharp, K Bertoglio, B Stamova, B P Ander, A D Sossong, R L Hendren Pharmacogenomics J 12 (5), 368-71. Oct 2012. PMID 21647175.
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Stroke and tPARNA in Blood Is Altered Prior to Hemorrhagic Transformation in Ischemic Stroke Glen C Jickling, Bradley P Ander, Boryana Stamova, Xinhua Zhan, Dazhi Liu, Lena Rothstein, Piero Verro, Jane Khoury, Edward C Jauch, Arthur M Pancioli, Joseph P Broderick, Frank R Sharp. Ann Neurol 74 (2), 232-40. Aug 2013. PMID 23468366.
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